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采用人关节滑膜细胞体外培养的方法，研究甲基强的松龙对滑膜细胞生物学特性的影响。结果发现：细胞接触甲基强的松龙在２０天、２０－８０微克／毫升条件下，细胞的分裂速度明显加快，细胞外基质蛋白质分泌减少，形态由梭形向多角形转变，电镜下细胞内骨骼由发达转为不发达，细胞内开始合成胶原纤维，细胞内发达的粗面内质网和线粒体说明细胞并非处于退变。此外，本实验证明细胞接触药物时间较短不能改变细胞的生物学性状。
Human synovial cells cultured in vitro method to study the methylprednisolone on the biological characteristics of synovial cells. The results showed that the cells were exposed to methylprednisolone at 20-80 microg / ml for 20 days, the cell division speed was significantly accelerated, the secretion of extracellular matrix protein was reduced, and the morphology changed from shuttle shape to polygonal shape. Under electron microscope, Endoskeleton from developed to underdeveloped, intracellular synthesis of collagen fibers began to develop intracellular rough endoplasmic reticulum and mitochondria that cells are not in degeneration. In addition, this experiment proved that cells exposed to drugs for a short time can not change the biological characteristics of cells.