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大量临床和实验研究表明,肾脏间质纤维化是导致终末期肾功能衰竭的最终途径。而作为炎症细胞中重要成员的肥大细胞,其合成和分泌的介质如糜蛋白酶、类胰蛋白酶、组胺、肝素和细胞因子如肿瘤坏死因子-α、转化生长因子-β等,通过多种途径刺激成纤维细胞的增多和细胞外基质的过度积聚,进而在肾脏间质纤维化中起着不可忽视的作用。因此,深入研究肥大细胞参与肾间质纤维化的详细机制,为肾脏纤维化的预防和治疗提供新的思路。
A large number of clinical and experimental studies have shown that renal interstitial fibrosis is the ultimate pathway leading to end-stage renal failure. And as an important member of inflammatory cells, mast cells, its synthetic and secreted media such as chymotrypsin, tryptase, histamine, heparin and cytokines such as tumor necrosis factor-α, transforming growth factor-β and so on, through a variety of ways Stimulate the proliferation of fibroblasts and excessive accumulation of extracellular matrix, which in turn plays an important role in renal interstitial fibrosis. Therefore, in-depth study of mast cells involved in renal interstitial fibrosis in detail the mechanism for the prevention and treatment of renal fibrosis provide a new way of thinking.