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铑(II)催化重氮苄基膦酸酯与芳香亚胺反应,一步合成氮杂环丙烷-2-膦酸酯.该方法立体定向地得到唯一的反式构型产物,反应历程是重氮化合物先与亚胺形成叶立德中间体,然后发生自身环丙烷化反应.
The rhodium (II) -catalyzed diazobenzylphosphonate reacted with aromatic imine to synthesize the aziridine-2-phosphonate in one step.The method was stereospecific to obtain the only trans-configuration product.The reaction course was diazo The compound first forms a ylide intermediate with the imine and then undergoes its own cyclopropanation reaction.