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随着骨髓移植的成功和骨髓培养技术的进展,对再生障碍性贫血(简称再障)的发病机理和治疗进行了大量研究。本文综述再障的几种病因,并较详细地阐述免疫和其它有关的发病机理,以及目前治疗研究的情况。所研究的范围主要局限在后天获得性严重全血细胞减少和骨髓增生低下的病例。病因约50%的再障其病因与药物或化学品有关,比较常见为:氯霉素(61%),保泰松(19%),抗惊厥药(4%),磺胺类(3%),金(3%),苯(2%),杀虫剂(4%),溶媒(4%)。氯霉素与本病的关系最密切,可产生两种
With the success of bone marrow transplantation and bone marrow culture technology, a great deal of research has been done on the pathogenesis and treatment of aplastic anemia (referred to as aplastic anemia). This article reviews several causes of aplastic anemia and provides a more detailed explanation of the immune and other related pathogenesis, as well as the current state of therapeutic research. The scope of the study was largely limited to cases of acquired acquired pancytopenia and low myeloproliferation. The cause of about 50% of the causes of aplastic anemia and drugs or chemicals related to the more common are: chloramphenicol (61%), phenylbutazone (19%), anticonvulsants (4%), sulfonamides (3% , Gold (3%), benzene (2%), insecticide (4%), vehicle (4%). Chloramphenicol and the most closely related to the disease, can produce two