茶碱的治疗指数狭窄,通常认为其血浆浓度应维持在10～20μg/ml。曾报道当给予氢化可的松时可致茶碱毒性反应,因而对任一皮质类固醇对茶碱稳态血浆浓度的影响进行了研究。 7名志愿受试者服用茶碱缓释剂。每天2次,直至获得稳态血浆浓度(13.9μg/ml)。然后每一受试患者分别接受氢化可的松(8mg/kg)、或给 Theophylline has a narrow therapeutic index and is generally considered to maintain its plasma concentration at 10-20 μg / ml. It has been reported that when given hydrocortisone can cause theophylline toxic reaction, thus any corticosteroid theophylline steady-state plasma concentrations were studied. Seven volunteers took a theophylline slow-release agent. Twice a day until a steady-state plasma concentration (13.9 μg / ml) was obtained. Each subject then received hydrocortisone (8 mg / kg), or given