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[目的]探讨PTEN和P16基因蛋白在胆囊癌组织中表达的意义。[方法]应用免疫组织化学技术检测58例胆囊腺癌、20例胆囊腺瘤和20例慢性胆囊炎组织中PTEN和P16基因蛋白表达。[结果]胆囊癌患者PTEN和P16表达阳性率分别为43.1%(25/58)和37.9%(22/58),其表达阳性率均明显低于胆囊腺瘤和慢性胆囊炎(P<0.05)。PTEN和P16表达与胆囊癌的分化程度、浆膜浸润和转移相关(P<0.05)。[结论]检测PTEN和P16基因蛋白表达可作为评估胆囊癌生物学行为和预后的参考指标。
[Objective] To investigate the expression of PTEN and P16 gene in gallbladder carcinoma. [Method] Immunohistochemistry was used to detect the protein expression of PTEN and P16 in 58 cases of gallbladder adenocarcinoma, 20 cases of gallbladder adenoma and 20 cases of chronic cholecystitis. [Results] The positive rates of PTEN and P16 expression in gallbladder carcinoma were 43.1% (25/58) and 37.9% (22/58), respectively, which were significantly lower than those of gallbladder adenoma and chronic cholecystitis (P <0.05) . The expression of PTEN and P16 were correlated with the differentiation of gallbladder carcinoma, serosa invasion and metastasis (P <0.05). [Conclusion] Detecting the expression of PTEN and P16 gene protein can be used as a reference index to evaluate the biological behavior and prognosis of gallbladder carcinoma.