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目的：评价体部伽玛刀治疗Ⅰ、Ⅱ期非小细胞肺癌的疗效及毒副作用。方法52例Ⅰ期和Ⅱ期（T1-3N0M0）非小细胞肺癌患者接受国产旋转式体部伽玛刀治疗，治疗时用真空负压袋固定体位，CT定位扫描作三维计划。照射剂量肿瘤边缘（50%剂量线）4～5 Gy/次，5次/周，肿瘤局部总剂量40～50 Gy。结果原发灶近期完全缓解率CR为65.4%（34/52），部分缓解率PR为30.8%（16/52），稳定NR为1.9%（1/52），总有效率为98.1%（51/52）。52例全部按计划完成治疗，放射反应轻。放射性肺炎Ⅰ级占7.7%（4/52），Ⅱ级占3.8%（2/52），放射性食管炎：周围性肺癌0，中心型肺癌6例11.5%（6/52）。白细胞下降Ⅰ级占5.8%（3/52），Ⅱ级占1.9%（1/52）。1、2、3年总生存率分别为90.4%（47/52）、78.8%（41/52）、69.2（36/52）。结论体部伽玛刀治疗早期非小细胞肺癌近期疗效好，放射反应轻，能为患者耐受，是不能接受手术治疗的早期非小细胞肺癌的一种安全有效的局部治疗手段。“,”ObjectiveTo study the curative effect and side effect of Body-Gamma Knife radiotherapy in treating with 52 cases of stage I and stage II non-small cell lung cancer.Methods52 cases of non-small lung cancer in stage I and stage II (T1,2,3N0M0) were treated with rotary body gamma knife. Patients were fixed with vacuum bag, CT imitates to position and stereospic plan treatment. Irradiation dosage: tumor edge (50% dose line) 4-5 Gy/fraction, 5 times/week, total dose of tumor 40-50Gy. ResultsThe recent complete remission rate of primary lesion is CR 65.3%(34/52); partial remission rate is PR30.7%(16/52),while 0.01%(1/52) is no remission. Overall response rate is 98.0%(51/52). All the 52 cases were complete treatment on schedule with less complications of radiotherapy, 0.07%(4/52) with stage I radiation pneumonitis, 0.03%(2/52) with stage II radiation pneumonitis, 11.5%(6/52) with radiation esophagitis, 0.05%(3/52)with stage I leucopenia and 0.01%(1/52)with stage II leucopenia. The 1, 2, 3-year survival rate is 90.3%(47/52), 78.8%(41/52), 69.2(36/52),respectively.ConclusionBody-Gamma Knife, with good sort-term effects and less radiotherapy complications, is an useful and safety way in treating with early-stage non-small cell lung cancer who with surgical contraindication.