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目的研究职业性铅作业工人血铅和尿酸的变化,探讨血铅浓度变化和血尿酸指标之间的关系。方法车间空气中铅烟的短时间接触浓度用原子吸收火焰法检测。选择一般情况可比的非铅作业工人作为对照,根据接触铅的浓度是否超过职业限值将263名铅接触工人分为职业限值内组及超职业限值组。分析不同血铅水平和血尿酸指标的变化。结果 (1)车间空气中铅烟的时间加权平均容许浓度(PC-TWA)达0.13mg/m3,超标率为68.61%;(2)接铅超职业限值组血铅浓度达(3.16±0.03)μmol/L、尿酸为(528±109.48)μmol/L,均显著高于对照组(P﹤0.05);(3)血铅浓度的变化和尿酸异常率存在一致的变化趋势。结论职业性铅接触引起血铅浓度升高和血尿酸升高,且血铅浓度越高,血尿酸升高程度越大。
Objective To study the changes of blood lead and uric acid in professional lead workers and explore the relationship between blood lead concentration and serum uric acid. Methods Short exposure time of lead smoke in workshop air was measured by flame atomic absorption spectrometry. As a control, non-lead workers were selected as comparable and were divided into occupational limit groups and over-occupational limit groups based on whether lead exposure exceeded the occupational limit. Analysis of different blood lead levels and changes in serum uric acid indicators. Results (1) The time weighted average allowable concentration (PC-TWA) of lead in the air of the workshop reached 0.13mg / m3, and the exceeding standard rate was 68.61%. (2) ) (μmol / L) and uric acid (528 ± 109.48) μmol / L, both of which were significantly higher than those of the control group (P <0.05). (3) There was a consistent trend of change of blood lead concentration and uric acid anomaly rate. Conclusion Occupational lead exposure causes elevated blood lead levels and elevated serum uric acid, and the higher the blood lead level, the greater the elevated serum uric acid.