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目的:观察乌灵胶囊联合西酞普兰治疗慢性紧张性头痛的疗效和安全性。方法:96例慢性紧张性头痛患者随机分成2组,各48例。对照组给予西酞普兰,观察组给予鸟灵胶囊加西酞普兰,疗程12周。用汉密尔顿抑郁、焦虑量表(HAMD、HAMA)、疼痛评分和不良反应量表(TESS)进行疗效和不良反应评定。结果:2组疗效比较,差异无统计学意义(P>0.05)。观察组不良反应较对照组轻,差异有统计学意义(P<0.01)。结论:乌灵胶囊联合西酞普兰治疗慢性紧张性头痛有效、安全,能提高慢性紧张性头痛患者对西酞普兰的耐受性。
Objective: To observe the curative effect and safety of Wuling capsules combined with citalopram in the treatment of chronic tension-induced headache. Methods: Ninety-six patients with chronic tension-induced headache were randomly divided into two groups (n = 48). The control group was given citalopram, the observation group was given bird capsule plus citalopram, treatment for 12 weeks. The Hamilton Depression, Anxiety Scale (HAMD), Pain Rating and TESS were used to evaluate the efficacy and adverse reactions. Results: There was no significant difference between the two groups (P> 0.05). Adverse reactions in the observation group were lighter than those in the control group, with statistical significance (P <0.01). Conclusion: Wuling capsule combined with citalopram in the treatment of chronic tension-induced headache is effective and safe, which can improve the tolerance of citalopram in patients with chronic tension-induced headache.