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目的探讨胃黏膜中EGF、EGFR与胃癌的关系。方法应用免疫组化S-P法对199例胃癌、20例正常胃黏膜及20例不典型增生胃黏膜中的EGF及EGFR进行检测。结果有淋巴结转移、远处转移及胃癌中EGFR的表达水平(阳性率分别为61.1%、66%、66.7%)较其它癌组织、正常胃黏膜、不典型增生胃黏膜(阳性率分别为47.83%、0%、35%)高(P<0.01)。EGF及EGFR的阳性表达部位均在胞膜和胞浆。EGFR的阳性表达与肿瘤的分化程度、侵袭及淋巴结具有相关性。结论EGF及EGFR对胃癌的早期诊断有重要意义,可作为胃癌术前判断是否复发、转移的危险性指标。
Objective To investigate the relationship between EGF, EGFR and gastric cancer in gastric mucosa. Methods Immunohistochemical S-P method was used to detect EGF and EGFR in 199 cases of gastric cancer, 20 cases of normal gastric mucosa and 20 cases of atypical hyperplastic gastric mucosa. Results There were lymph node metastasis, distant metastasis and the expression of EGFR in gastric cancer (positive rates were 61.1%, 66%, 66.7% respectively) than those in other cancerous tissues, normal gastric mucosa and atypical hyperplastic gastric mucosa (the positive rates were 47.83% , 0%, 35%) (P <0.01). EGF and EGFR positive expression sites are in the membrane and cytoplasm. The positive expression of EGFR was correlated with the degree of tumor differentiation, invasion and lymph node. Conclusion EGF and EGFR are of great significance in the early diagnosis of gastric cancer, which can be used as a risk indicator of gastric cancer recurrence and metastasis before operation.