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Th2淋巴细胞的优势应答及其释放的细胞因子被认为在哮喘的发病过程中起关键性作用。IL-13可不依赖于其它Th2型细胞因子及嗜酸粒细胞、Ig-E介导的途径而单独诱发哮喘的所有症状。IL-13基因多态性与哮喘的易感性也密切相关。其拮抗剂的应用有望成为哮喘病防治的新方法。
The predominant response of Th2 lymphocytes and the cytokines they release are thought to play key roles in the pathogenesis of asthma. IL-13 alone induces all symptoms of asthma independent of other Th2-type cytokines and eosinophils, Ig-E-mediated pathways. IL-13 gene polymorphism and asthma susceptibility are also closely related. Its antagonist application is expected to become a new method of prevention and treatment of asthma.