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目的探讨细管胸腔引流并注入尿激酶治疗包裹(多房)性胸腔积液的临床价值。方法对28例包裹(多房)性胸腔积液患者先行细管胸腔闭式引流,液体流净后注入生理盐水50 ml稀释的尿激酶12.5万U,然后闭管,24小时后排空液体,如果仍有分隔或积液,重复上述治疗。结果28例患者中有24例仅一次尿激酶治疗后有效,仅2例无效,总有效率96.4%。注入尿激酶后第一次排液量较用药前明显增多(P<0.05),而2～3次用药后排液量增多不及第一次明显(P>0.05)。结论细管胸腔引流并注入尿激酶治疗包裹(多房)性胸腔积液是治疗包裹(多房)性胸腔积液的一种安全、有效的方法,可使绝大多数患者避免了手术治疗。
Objective To investigate the clinical value of tubule drainage and injection of urokinase in parietal pleural effusion. Methods Thirty-eight patients with paroxysmal pleural effusion underwent closed thoracic drainage of the thoracic cavity. After the fluid flow was clean, 50 ml diluted urokinase of physiological saline was injected into the lumen and then closed. After 24 hours, the fluid was emptied, If there are still sepsis or fluid, repeat the above treatment. Results Twenty-four of the 28 patients were only treated once with urokinase and only 2 patients were ineffective with a total effective rate of 96.4%. The amount of fluid discharge after urokinase injection was significantly increased (P <0.05) before administration, while the amount of fluid excretion after 2 or 3 administrations was less than the first time (P> 0.05). Conclusion Thoracic drainage and injection of urokinase in paroxysmal pleural effusion are a safe and effective method for the treatment of paroxysmal pleural effusion. Most patients can avoid surgery.