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目的探讨乳腺癌中微淋巴管密度(MLVD)与淋巴结转移间的关系。方法应用免疫组化SP法,检测60例乳腺癌间质中淋巴管特异性标记物D2-40的表达,并计数MLVD。结果MLVD与腋下淋巴结转移及乳腺癌患者的临床分期明显相关,腋下淋巴结转移组的淋巴管密度明显高于腋下淋巴结无转移组(P<0.05);临床分期越晚,肿瘤淋巴管密度越大(P<0.05)。结论MLVD与乳腺癌淋巴管生成及乳腺癌腋下淋巴结转移密切相关。
Objective To investigate the relationship between lymphatic vessel density (MLVD) and lymph node metastasis in breast cancer. Methods Immunohistochemical SP method was used to detect the expression of lymphatic-specific marker D2-40 in 60 breast carcinoma stroma and MLVD was counted. Results MLVD was significantly associated with lymph node metastasis in axillary lymph nodes and clinical stage of breast cancer patients. The density of lymphatic vessels in axillary lymph node metastasis group was significantly higher than that in axillary lymph node metastasis group (P <0.05). The later clinical stage, the lymphatic vessel density The greater (P <0.05). Conclusion MLVD is closely related to lymphangiogenesis in breast cancer and axillary lymph node metastasis in breast cancer.