论文部分内容阅读
目的:探讨pN0声门上型喉癌瘤内微血管密度(IMVD)与颈淋巴结微转移的相关性及其临床意义。方法:分别应用CD105和CK19单克隆抗体进行免疫组织化学SABC法检测pN0声门上型喉癌IMVD及颈淋巴结微转移灶。结果:CD105标记的IMVD与喉癌的T分期和颈淋巴结微转移密切相关(P<0.01)。结论:pN0喉癌IMVD与颈淋巴结微转移高度相关,二者可作为pN0喉癌患者独立的预后指标。
Objective: To investigate the correlation between microvessel density (IMVD) and cervical lymph node micrometastasis in pN0 supraglottic laryngeal carcinoma and its clinical significance. Methods: Immunohistochemical SABC method was used to detect the IMVD of supratentorial laryngeal carcinoma of pN0 and the cervical lymph node micrometastasis by using monoclonal antibodies against CD105 and CK19 respectively. Results: CD105-labeled IMVD was closely related to T stage and cervical lymph node micrometastasis of laryngeal carcinoma (P <0.01). CONCLUSION: IMVD in pN0 laryngeal carcinoma is highly correlated with cervical lymph node micrometastasis, both of which can be used as independent prognostic indicators in patients with pN0 laryngeal cancer.