论文部分内容阅读
目的通过对高血压合并2型糖尿病患者血糖水平的控制,探讨不同血糖水平对降压疗效及内皮功能的影响。方法选择住院和门诊高血压合并2型糖尿病患者68例,根据高血压和2型糖尿病治疗指南选择降压和降糖方案,记录患者治疗过程中不同血糖水平时的降压疗效,同时检测治疗开始与结束时的空腹血糖(FPG)、血浆内皮素(ET-1)及尿清蛋白排泄率(Urinary albumin excretion rate,UAER)。结果随着治疗过程中血糖水平的逐渐改善,血压达标人数明显增加。经过4～6周的降糖治疗,血糖接近达标(6.1～6.9mmol/L)和达标(<6.1mmol/L)时,血压达标率分别为82.35%和95.59%,和血糖≥7.0mmol/L(血压达标率51.47%)及≥7.8mmol/L(血压达标率27.94%)水平相比有显著性差异;同时,治疗前后患者FPG、血浆ET-1及UAER均明显下降。结论高血压合并2型糖尿病患者血糖水平与降压疗效关系密切,良好的血糖控制有利于血压的治疗,从而改善内皮功能,更好地预防靶器官损害,防止并发症的发生。
Objective To investigate the effects of different blood glucose levels on antihypertensive efficacy and endothelial function by controlling blood glucose levels in patients with type 2 diabetes mellitus and hypertension. Methods Sixty-eight inpatients and outpatients with type 2 diabetes mellitus were enrolled in this study. Blood pressure lowering and hypoglycemic regimens were selected according to the guidelines of hypertension and type 2 diabetes mellitus. The antihypertensive effects of different blood glucose levels during the course of treatment were recorded. And the end of fasting blood glucose (FPG), plasma endothelin (ET-1) and urinary albumin excretion rate (UAER). Results With the gradual improvement of blood glucose during the course of treatment, the number of blood pressure reached a marked increase. After 4 to 6 weeks of hypoglycemic treatment, the blood pressure compliance rates were 82.35% and 95.59% respectively when the blood glucose reached the standard (6.1-6.9mmol / L) and the standard (<6.1mmol / L), and the blood glucose was 7.0mmol / L (Blood pressure compliance rate of 51.47%) and ≥7.8mmol / L (blood pressure compliance rate of 27.94%) levels were significantly different; at the same time, before and after treatment in patients with FPG, plasma ET-1 and UAER were significantly decreased. Conclusions The blood glucose level in patients with hypertension complicated with type 2 diabetes is closely related to the antihypertensive effect. Good blood sugar control is beneficial to the treatment of blood pressure so as to improve endothelial function, prevent target organ damage and prevent the occurrence of complications.