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目的 探讨非那雄胺 (保列治 )对前列腺增生症术中和术后出血的疗效及机制。 方法 应用免疫组化S P法检测 43例服药组和 46例未服药组前列腺组织中CD3 4、bcl 2、PCNA和VEGF的表达。分析比较二组临床资料及免疫组化指标。 结果 服药组术中输血人数、输血量及术后继发性血尿的发生率较对照组均明显减少 ,两组间差别有显著性意义 (P <0 .0 5 )。免疫组化结果显示前列腺组织中血管密度及血管内面积较对照组明显减少 ,两组差别有非常显著性意义 (P <0 .0 1)。两组前列腺组织中bcl 2、PCNA和VEGF阳性表达率差别有显著性意义 (P <0 .0 1) ,表现为服药组较未服药组明显减弱。 结论 非那雄胺通过抑制前列腺组织中微血管形成 ,已形成血管的收缩 ,促进凋亡 ,抑制VEGF合成和前列腺增殖而防止和减少术中及术后出血
Objective To investigate the efficacy and mechanism of finasteride (Proliferation) on intraoperative and postoperative bleeding in patients with benign prostatic hyperplasia. Methods The expressions of CD34, bcl2, PCNA and VEGF were detected by immunohistochemical SP method in 43 cases of medication group and 46 cases of non-medication group. The clinical data and immunohistochemical indexes of two groups were analyzed and compared. Results The number of blood transfusion, blood transfusion and postoperative hematuria in the medication group were significantly lower than those in the control group. There was significant difference between the two groups (P <0.05). Immunohistochemistry results showed that the density of blood vessels and the area of blood vessels in prostate tissue were significantly decreased compared with the control group, the difference between the two groups was significant (P <0.01). The positive rates of bcl-2, PCNA and VEGF in the two groups of prostate tissue were significantly different (P <0.01), which showed that the medication group was significantly weaker than the non-medication group. Conclusion Finasteride can prevent and reduce the intraoperative and postoperative bleeding by inhibiting the formation of microvessels in prostate tissue, forming the vasoconstriction, promoting the apoptosis, inhibiting the synthesis of VEGF and prostatic hyperplasia