论文部分内容阅读
为研究肝脂酶及脂蛋白脂酶在胆固醇结石成石过程中的变化及其对成石的影响，采用高胆固醇膳食诱发兔胆囊胆固醇结石模型，观测对照组及高胆固醇膳食1、2、3、4周组动物血浆脂蛋白脂酶（LPL）、肝脂酶（HL）活性、血浆脂蛋白胆固醇及胆汁中甘氨胆酸（GCA）、甘氨脱氧胆酸（GDCA）、胆固醇的变化。结果显示：随着进食高胆固醇膳食时间的增加，血中LPL活性增高明显（P＜0．05）；HL活性也逐渐升高，3周组及4周组与对照组差异显著（P＜0.05）；血中VLDL－C、LDL－C及胆汁中胆固醇也明显升高（P＜0．05）；而血中HDL－C、HDL2－C及HDL3－C以及胆汁中GCA、GDCA无明显变化（P＞0．05）。结果表明：LPL及HL活性升高可能使肝脏摄取及向胆汁中排泌胆固醇增加，进而影响结石形成。
In order to study the changes of hepatic lipase and lipoprotein lipase in stone formation of cholesterol calculus and its effect on stone formation, the cholesterol gallstone cholesterol gallstone model was induced in rabbits with hypercholesterolemia. The rats in control group and high cholesterol diet 1, (LPL), hepatic lipase (HL) activity, plasma lipoprotein cholesterol and GCA, GDCA and cholesterol in the 4 weeks group. The results showed that the LPL activity increased significantly (P <0.05), the activity of HL increased gradually with the increase of meal time, and there was significant difference between the three weeks and the fourth weeks (P <0.05) ). The blood levels of VLDL-C, LDL-C and bile cholesterol were also significantly increased (P <0.05). There was no significant difference in HDL-C, HDL2-C, HDL3-C and GCA, (P> 0.05). The results show that: LPL and HL activity may increase liver uptake and secretion of bile cholesterol, thereby affecting the formation of stones.