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目的 观察化瘀清利合剂对自发性高血压大鼠 (SHR)血液流变学的影响。方法 选用自发性高血压大鼠 ,测定给药后模型动物血液流变学。结果 化瘀清利合剂治疗大、中剂量组均有降低全血粘度和血浆粘度的作用 ,在降低低切变率血粘度时呈量效关系 ;治疗大、中剂量组可改善红细胞的变形能力、降低红细胞刚性指数和聚集指数。结论 化瘀清利合剂可改善SHR血液流变学 ,对高血压大鼠有一定的保护作用。
Objective To observe the effect of Huayu Qingli mixture on hemorheology of spontaneously hypertensive rats (SHR). Methods Spontaneously hypertensive rats were selected to determine the hemorheology of model animals after administration. Results The Huayu Qinglie Mixture treatment for large and middle dose groups all had the effect of lowering the whole blood viscosity and plasma viscosity, showing a dose-effect relationship when lowering the low shear rate blood viscosity; the treatment of large and medium dose groups could improve the red blood cell deformability. Reduce red blood cell rigidity index and aggregation index. Conclusion Huayu Qingli Mixture can improve the hemorheology of SHR and has a certain protective effect on hypertensive rats.