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多发性硬化(简称MS)的诊断,目前主要依靠临床表现。有关实验室诊断,近年作过许多研究。1950年Freedman氏报告本病患者有58％表现脑脊液胶金曲线异常。1951年Do-novan氏发现病人脑脊液有r-球蛋白增高,程度与胶金曲线异常平行。1967年Link氏报告额外的免疫球蛋白带,以后被称为寡系免疫球蛋白(Oligoclonal immunoglobulin)。目前国外报告脑脊液中发现寡系免疫球蛋白(简称IgG)是多发性硬化症的一个重要特征。国内文献尚未见有关多发性硬化的此项报告。我院自81年以来共检查9例多发性硬化的寡系IgG,与14例其他神经系统疾病作对比。现将结果初步整理报告。
Multiple sclerosis (referred to as MS) diagnosis, mainly rely on clinical manifestations. There have been many studies on laboratory diagnosis in recent years. In 1950, Freedman’s report showed that 58% of patients with cerebrospinal fluid abnormalities of gold and silver curve. 1951 Do-novan found that patients with cerebrospinal fluid r-globulin increased, the degree of abnormal and plastic gold curve parallel. In 1967, Link’s reported additional immunoglobulin bands, which were later referred to as Oligoclonal immunoglobulin. At present, foreign reports of cerebrospinal fluid found in oligo-immunoglobulin (referred to as IgG) is an important feature of multiple sclerosis. Domestic literature has not seen this report on multiple sclerosis. A total of 9 polycystic IgG with multiple sclerosis were examined in our hospital since 81 years, compared with 14 other neurological diseases. Now the results of the initial finishing report.