[目的]探讨腹腔镜下根治性全膀胱切除术中经食道超声心动图(TEE)容量指导补液治疗对患者主要肾功能指标β2微球蛋白(β2MG)、尿蛋白和尿肌酐(UCr)的影响.[方法]160 例膀胱癌患者,随机分为TEE容量指导补液治疗组(观察组)和常规补液治疗组(对照组),每组 80例.比较两组患者的主要肾功能指标变化和术后并发症发生情况.[结果]两组患者手术前各指标相比较差异均无显著性(P ＞0.05),观察组患者术后 d3 的β2MG、血尿素氮(BUN)、血肌酐(Scr)、UCr和 24 h尿蛋白水平明显低于对照组,且差异均有显著性(P ＜0.05).观察组患者住院时间为(11.36±1.47)d明显少于对照组的(16.23±1.51)d,且差异有显著性(P ＜0.05);观察组患者早期并发症和晚期并发症发生率均显著低于对照组(P ＜0.05).[结论]腹腔镜下根治性全膀胱切除术中使用TEE容量指导补液治疗可以有效改善和提高患者术后的肾功能情况,减少患者术后并发症.“,”[Objective]To investigate the effect of transesophageal echocardiography (TEE)capacity guidance rehydration on the renal function indexes macroglobulin (β2MG),proteinuria and urinary creatinine (UCr)in patients undergoing laparoscopic radical cystectomy of bladder cancer.[Methods]A total of 160 patients with bladder cancer were enrolled.They were randomly divided into the TEE capacity guidance rehydration treatment group (observation group)and the conventional rehydration treatment group (control group), with 80 cases in each group.Data of cardiac function,major renal function index and postoperative complications in patients were recorded and compared in the tow groups.[Results]There were no significant differences in the above indexes between the two groups before operation (P＞0.05).Compared to the control group,the levels of renal function indexesβ2MG,BUN,SCr,UCr and 24h urine protein in the observation group were much lower;the differences were statistically significant (P ＜0.05).The hospitalization time of the observation group was (11.36±1.47)d,which was significantly less than that of the control group (16.23 ± 1.51)d, and the difference was significant (P＜0.05).The incidence of early complications and late complications were significantly lower in the observation group than in the control group (P ＜0.05).[Conclusion]TEE capacity guidance rehydration therapy can effectively improve postoperative renal function and reduce postoperative complications.