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目的依托齐齐哈尔医学院三所附属医院和齐齐哈尔市第一医院的临床资源,建立一个系统的、规范的乳腺癌组织标本库,为临床和科学研究者提供合适数量的肿瘤标本,从而促进乳腺癌发病机理的研究。方法收集乳腺癌患者手术切除后的新鲜肿瘤组织,包括肿瘤组织1.5 cm距离的癌旁组织、肿瘤组织和距离肿瘤组织>5 cm的切缘远端非肿瘤组织以及肿瘤患者的全血和血清/血浆标本。采用一套信息管理体系对于标本进行管理,所有的标本及其相关临床信息资料均录入数据库,可随时调用和查询。结果从2012年6月创建至2015年3月,共收集261例乳腺癌患者新鲜组织;全血和血清共1 989份,全套标本者176例。结论建立了一套系统的,具有一定规模的乳腺癌组织标本资源库,形成了规范的管理办法和建设规划,为今后乳腺癌的基础与临床研究提供物质与信息资源。
Objective To establish a systematic and standardized database of breast cancer tissue relying on the clinical resources of the three affiliated hospitals of Qiqihar Medical College and the First Hospital of Qiqihar to provide clinical and scientific researchers with the appropriate number of tumor samples to promote the development of breast cancer Mechanism of research. Methods Fresh tumor tissues were collected from patients with breast cancer after resection, including paracancerous tissues at a distance of 1.5 cm from the tumor tissue, tumor tissues and distal margin non-tumor tissues at the margin> 5 cm away from the tumor tissue, and whole blood and serum / Plasma samples. A set of information management system for the management of specimens, all specimens and related clinical information are entered into the database, and can be invoked at any time. RESULTS: From June 2012 to March 2015, a total of 261 breast cancer fresh tissue samples were collected; 1 989 whole blood and serum samples were obtained, and 176 were included in the complete set. Conclusion A systematic and certain scale breast cancer tissue resource database was established and a standardized management approach and construction plan was established to provide material and information resources for the future basic and clinical research of breast cancer.