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目的:探讨老年人头面部血管肉瘤的临床和病理特征。方法:分析9例患者的临床特点,观察其常规组织病理变化及CD31、CD34、Ⅷ相关因子(FⅧ)免疫组化标记特点。结果:该病发病年龄平均71.4岁,男:女为2:1,临床早期常在头面部出现淤斑样皮损,后期发生浸润性暗红斑,伴结节及溃疡,易破溃出血。组织病理检查示真皮广泛血管增生及浸润,组织形态变异较大,常见细胞异形。CD31、CD34、FⅧ均可标记内皮细胞,在管腔明显区域表达强,实体瘤区域表达弱或不表达。结论:老年人头面部出现淤斑样皮损时,应及时做组织病理检查,早期明确诊断。CD31、CD34、FⅧ免疫组化标记有助于明确其来源。目的:探讨老年人头面部血管肉瘤的临床和病理特征。方法:分析9例患者的临床特点,观察其常规组织病理变化及CD31、CD34、Ⅷ相关因子(FⅧ)免疫组化标记特点。结果:该病发病年龄平均71.4岁,男:女为2:1,临床早期常在头面部出现淤斑样皮损,后期发生浸润性暗红斑,伴结节及溃疡,易破溃出血。组织病理检查示真皮广泛血管增生及浸润,组织形态变异较大,常见细胞异形。CD31、CD34、FⅧ均可标记内皮细胞,在管腔明显区域表达强,实体瘤区域表达弱或不表达。结论:老年人头面部出现淤斑样皮损时,应及时做组织病理检查,早期明确诊断。CD31、CD34、FⅧ免疫组化标记有助于明确其来源。
Objective: To investigate the clinical and pathological features of elderly patients with head and facial angiosarcoma. Methods: The clinical features of 9 patients were analyzed. The histopathological changes and the features of CD31, CD34 and VIII related factor (FVIII) immunohistochemical markers were analyzed. RESULTS: The average age of the disease was 71.4 years old, male and female were 2:1. In early clinical stage, there were ecchymatous lesions on the head and face, infiltrative dark erythema in the later stage, nodules and ulcers, and easy to rupture bleeding. Histopathological examination revealed extensive vascular hyperplasia and infiltration of the dermis, with large histological variability and common cell abnormalities. CD31, CD34, and FVIII all stained endothelial cells and expressed strongly in the luminal area. The solid tumor area showed weak or no expression. Conclusion: When ecchymatous skin lesions occur in the head and face of the elderly, the histopathologic examination should be performed promptly to confirm the diagnosis early. The immunohistochemical markers of CD31, CD34, and FVIII help clarify the source. Objective: To investigate the clinical and pathological features of elderly patients with cephalothoracular angiosarcoma. Methods: The clinical features of 9 patients were analyzed. The histopathological changes and the features of CD31, CD34 and VIII related factor (FVIII) immunohistochemical markers were analyzed. RESULTS: The average age of the disease was 71.4 years old, male and female were 2:1. In early clinical stage, there were ecchymatous lesions on the head and face, infiltrative dark erythema in the later stage, nodules and ulcers, and easy to rupture bleeding. Histopathological examination showed extensive vascular proliferation and infiltration of the dermis, with a large variation in histomorphology and common cell abnormalities. CD31, CD34, and FVIII all stained endothelial cells and expressed strongly in the luminal area. The solid tumor area showed weak or no expression. Conclusion: When ecchymatous skin lesions occur in the head and face of the elderly, the histopathologic examination should be performed promptly to confirm the diagnosis early. The immunohistochemical markers of CD31, CD34, and FVIII help clarify the source.