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目的:分析前列地尔在脑卒中患者冠状动脉旁路移植(CABG)术后对患者神经系统并发症预防性的影响。方法:选取首都医科大学附属安贞医院心外科六病区的收治脑卒中冠状动脉旁路移植术后患者60例,随机分为两组,每组30例患者,其中对照组予常规肠外营养(PN)治疗,实验组加用前列地尔治疗。对比治疗前后两组患者神经系统功能及临床疗效。结果:1治疗后2组患者临床症状均有所减轻,实验组总有效率(100%)率明显优于对照组(80.0%),差异有显著的统计学意义(P<0.05);2治疗结束后,实验组和对照组分别有4例、9例患者出现神经系统并发症状,实验组神经系统并发症的发生率为13.3%明显低于对照组30%,差异有统计学意义(P<0.05)。3经logistic回归分析统计,术后神经系统并发症影响因素与性别无明显差异(P>0.05),与颈动脉重度狭窄、缺血缺氧性脑病以及脑卒中存在差异,有显著的统计学意义(P<0.05)。结论:前列地尔注射液能有效的预防脑卒中患者CABG术后预防神经系统并发症,对临床具有指导意义。
Objective: To analyze the preventive effect of alprostadil on neurological complications in patients with stroke after coronary artery bypass grafting (CABG). Methods: Sixty patients admitted to the Department of Cardiac Surgery, Anzhen Hospital, Capital Medical University, were randomly divided into two groups of 30 patients. The control group received conventional parenteral nutrition (PN) treatment, experimental group plus alprostadil treatment. Comparison of the two groups of patients before and after treatment of neurological function and clinical efficacy. Results: 1 After treatment, the clinical symptoms were relieved in both groups. The total effective rate (100%) in the experimental group was significantly better than that in the control group (80.0%), the difference was statistically significant (P <0.05) At the end of the experiment, there were 4 cases in the experimental group and the control group, 9 cases had neurological complications. The incidence of neurological complications was 13.3% in the experimental group, which was significantly lower than that in the control group (P < 0.05). The results of logistic regression analysis showed that there was no significant difference between postoperative neurological complications and sex (P> 0.05), significant difference with severe carotid stenosis, hypoxic ischemic encephalopathy and stroke (P <0.05). Conclusion: Alprostadil injection can effectively prevent postoperative CABG postoperative neurological complications in patients with stroke, which is of clinical significance.