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目的 :观察灵葜四君颗粒联合化疗治疗胃癌的临床疗效。方法 :80例胃癌术后患者随机分为治疗组(灵葜四君颗粒加化疗 )和对照组 (单纯化疗 )各 4 0例。观察治疗前后卡氏评分、外周血常规和血液流变学的变化 ,并观察自然杀伤 (NK)细胞、T淋巴细胞亚群、可溶性白细胞介素 2受体 (SIL 2R)等指标的变化。结果 :治疗组化疗后生存质量改善 ,外周血白细胞和红细胞数稳定 ;对照组外周血白细胞、红细胞数、血红蛋白浓度均较化疗前明显下降。治疗组化疗后NK细胞活性、CD3 、CD4阳性T细胞数和CD4/CD8比值升高 ,血清SIL 2R的浓度和全血粘度 (低切、中切、高切 )均明显下降 ;而对照组化疗后NK细胞活性、CD4阳性T细胞数和CD4/CD8比值下降 ,血清SIL 2R的浓度升高而全血粘度无明显改变。结论 :灵葜四君颗粒对化疗有增效减毒作用 ,对胃癌术后患者机体免疫功能有保护和促进作用 ,并能防治化疗引起的骨髓抑制 ,降低血液粘度。
Objective: To observe the clinical efficacy of Lingjing Sijun granule combined with chemotherapy in the treatment of gastric cancer. Methods: Eighty patients with gastric cancer were randomly divided into treatment group (Lingjing Sijun granule plus chemotherapy) and control group (chemotherapy alone), 40 cases each. The changes of Karnofsky Index, peripheral blood and hemorheology were observed before and after treatment. The changes of natural killer (NK) cells, T lymphocyte subsets and soluble interleukin 2 receptor (SIL 2R) were observed. Results: The quality of life of the treatment group improved after chemotherapy, the number of peripheral leukocytes and erythrocytes was stable. The levels of leukocytes, erythrocytes and hemoglobin in the control group were significantly lower than those before chemotherapy. The NK cell activity, the number of CD3, CD4 positive T cells and the ratio of CD4 / CD8 in the treatment group increased significantly, and the serum SIL 2R concentration and the whole blood viscosity (low, middle and high cut) were significantly decreased; while the control group chemotherapy After NK cell activity, CD4-positive T cells and CD4 / CD8 ratio decreased, the concentration of serum SIL 2R increased without any significant change in the whole blood viscosity. CONCLUSION: Lingjing Sijun Granule has synergistic effect and attenuating effect on chemotherapy. It can protect and promote the immune function of postoperative patients with gastric cancer, and can prevent and cure myelosuppression induced by chemotherapy and reduce blood viscosity.