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肌营养不良蛋白聚糖是一种与抗肌萎缩相关的糖蛋白复合体,是由α-肌营养不良蛋白聚糖和β-肌营养不良蛋白聚糖两种亚单位组成的跨膜糖蛋白,广泛分布于各种组织,特别是骨骼肌和神经系统。基质金属蛋白酶是细胞外的一大类锌依赖性肽链内切酶家族,其活性与肌营养不良蛋白的裂解密切相关,特别是基质金属蛋白酶-2和基质金属蛋白酶-9,又名明胶酶。文中就肌营养不良蛋白聚糖和明胶酶的结构、功能,及其相关性的研究现状进行综述。
Muscular dystroglycans, a glycoprotein complex associated with muscular dystrophy, is a transmembrane glycoprotein composed of two subunits, α-dystroglycan and β-muscular dystroglycan, Widely distributed in a variety of organizations, especially skeletal muscle and nervous system. Matrix metalloproteinases (MMPs) are a family of extracellular zinc-dependent endopeptidases whose activities are closely linked to the cleavage of dystrophin, especially MMP-2 and MMP-9, also known as gelatinases . This review summarizes the current status of the studies on the structure, function and correlation of dystroglycan and gelatinase.