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目的低分子肝素、羟-乙基淀粉和呋塞米联合应用治疗肾病综合征(PNS)水肿的疗效。方法将54例PNS患者分为2组,对照组(24例)给予糖皮质激素、血管紧张素转化酶抑制剂(ACEI)等常规治疗;试验组(30例)在此基础上加用低分子肝素钙针(5000U)皮下注射,4周为1个疗程。结果试验组有效率(90%)高于对照组(62.5%,P〈0.05)。试验组治疗后24h尿蛋白及总胆固醇较治疗前和对照组治疗后低,血清白蛋白水平升高。结论在激素及ACEI等药物治疗基础上,加用低分子肝素有利于PNS症状早期缓解,且不良反应少。
Objective To investigate the curative effect of low molecular weight heparin, hydroxyethyl starch and furosemide in the treatment of nephrotic syndrome (PNS) edema. Methods 54 cases of PNS patients were divided into two groups, the control group (24 cases) given glucocorticoid, angiotensin converting enzyme inhibitor (ACEI) and other conventional treatment; experimental group (30 cases) on the basis of the use of low molecular weight Heparin calcium needle (5000U) subcutaneous injection, 4 weeks for a course of treatment. Results The effective rate of the experimental group (90%) was higher than that of the control group (62.5%, P <0.05). Urine protein and total cholesterol in experimental group after treatment were lower than those before treatment and control group, serum albumin level increased. Conclusion On the basis of hormones, ACEI and other drugs, adding low molecular weight heparin is beneficial to early remission of PNS symptoms with less adverse reactions.