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目的总结分析无创机械通气联合盐酸氨溴索雾化在慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭患者治疗中的应用效果。方法选择2011年6月至2013年11月嵩县人民医院收治的90例慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭患者为研究对象,随机分为观察组和对照组各45例,对照组患者给予平喘、祛痰、抗感染、氧疗等常规治疗,观察组患者在此基础上给予无创机械通气联合盐酸氨溴索雾化治疗,比较两组患者治疗效果。结果治疗后两组p H指标之间比较差异未见统计学意义(P>0.05);但观察组Pa O2(78.40±3.22)mm Hg明显高于对照组,而Pa CO2(52.68±6.52)mm Hg明显低于对照组,两组间比较差异有统计学意义(P<0.05);观察组治疗总有效率95.56%明显高于对照组80.00%,差异有统计学意义(P<0.05)。结论在常规治疗基础上给予无创正压通气以及盐酸氨溴索雾化治疗对慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭患者具有积极治疗作用,值得推广应用。
Objective To summarize the effect of noninvasive mechanical ventilation combined with ambroxol hydrochloride atomization in the treatment of patients with chronic obstructive pulmonary disease and type Ⅱ respiratory failure. Methods From June 2011 to November 2013, 90 patients with chronic obstructive pulmonary disease and type Ⅱ respiratory failure admitted to Songxian People’s Hospital were enrolled and randomly divided into observation group (45 cases) and control group (45 cases). Patients in the control group Asthma, expectorant, anti-infective, oxygen therapy and other routine treatment, the observation group was given non-invasive mechanical ventilation on this basis with ambroxol hydrochloride atomization treatment, the treatment effect of two groups were compared. Results There was no significant difference in p H between two groups after treatment (P> 0.05). However, Pa O2 (78.40 ± 3.22) mm Hg in the observation group was significantly higher than that in the control group, while Pa CO2 (52.68 ± 6.52) mm Hg was significantly lower than the control group, the difference between the two groups was statistically significant (P <0.05); the total effective rate was 95.56% in the observation group was significantly higher than 80.00% in the control group, the difference was statistically significant (P <0.05). Conclusions Noninvasive positive pressure ventilation and ambroxol hydrochloride atomization therapy have positive curative effect on chronic obstructive pulmonary disease with type Ⅱ respiratory failure, which is worth popularizing and applying.