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从雄性SD断乳大鼠肝胞质液中提取的肝生长刺激物质,通过体外培养,证实其对LW13正常大鼠肝细胞系有明显的刺激作用,对K562人红白血病细胞系和兔表皮细胞的DNA合成无影响,对SMMC-7721人肝癌细胞系有明显的抑制作用,且有剂量效应关系。
The liver growth stimulating substance extracted from liver cytoplasm of male SD weanling rats was proved to have obvious stimulating effect on LW13 normal rat hepatocyte cell line by in vitro culture and the effect on K562 human erythroleukemia cell line and rabbit epidermal cells DNA synthesis had no effect on SMMC-7721 human hepatoma cell line was significantly inhibited, and the dose-response relationship.