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目的 研究急性中毒患者血浆内皮素浓度的临床价值。方法用放免和比色法测定６０例急性中毒患者血浆内皮素的浓度与正常对照组对比分析。结果轻度急性中毒患者血浆内皮素轻度升高，但无显著差异（Ｐ＞０．０５）；中度中毒患者明显升高（Ｐ＜０．０１）；重度中毒显著升高（Ｐ＜０．０１）。结论急性中毒患者中毒越重血浆内皮素升高越明显，可作为判断病情轻重和预后的一个重要指标。如何抑制血浆内皮素增加，对提高抢救急性中毒的成功率，减少病死率有一定的临床研究价值。
Objective To study the clinical value of plasma endothelin concentration in acute poisoning patients. Methods The levels of plasma endothelin in 60 acute poisoning patients were determined by radioimmunoassay and colorimetric method. The results were compared with the normal control group. Results Plasma endothelin was mildly elevated in patients with mild acute poisoning, but no significant difference was found (P> 0.05); patients with moderate poisoning were significantly increased (P <0.01); severe poisoning was significantly increased .01). Conclusion Patients with acute poisoning more severe poisoning increased plasma endothelin, the more obvious, can be used as judging severity and prognosis of an important indicator. How to inhibit the increase of plasma endothelin, to improve the success rate of rescue acute poisoning, reduce mortality has some clinical research value.