众所周知锂治疗可引起甲状腺功能异常.已报告者多为生化检验的甲状腺功能不足与非毒性甲状腺肿,但无临床现象,明显的甲状腺功能减退并不常见.曾有人报告(Sedvall等,1968;Shopsin,1970),服锂剂数周后发生甲状腺素分泌减少.还有人(Schou 1968等)报告数例在锂治疗数月或数年后出现甲状腺肿,并认为也系锂的晚发性副作用. It is well-known that lithium therapy can cause thyroid dysfunction, and many have reported biochemical tests for hypothyroidism and non-toxic goiter, but no clinical signs and no obvious hypothyroidism are uncommon.Recent reports (Sedvall et al., 1968; Shopsin , 1970), reduced thyroid hormone secretion after several weeks of serving lithium, and others (Schou 1968 et al.) Reported cases of goiter that occurred months or years after lithium treatment and were considered to be late-onset side effects of lithium.