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目的检测红细胞分布宽度(RDW)在冠心病患者外周血中的分布特点,探讨其临床应用价值。方法 227例冠心病患者作为冠心病组,健康人198例为健康对照组,采用血液分析系统检测外周血RDW水平,采用全自动生化仪检测C反应蛋白(CRP)、白介素-2(IL-2)、白介素-6(IL-6)及肿瘤坏死因子(TNF),讨论其相关性。结果冠心病组RDW3及RDW4分布多于健康对照组(P<0.01);冠心病组CRP及TNF水平呈现随RDW四分位数增高而升高趋势;Spearman相关性分析显示RDW与CRP水平有正相关性(r=0.171,P=0.036<0.05);吸烟、是否高血压及RDW是冠心病独立影响因素(P<0.05)。结论 RDW水平与冠心病具有相关性,可作为冠心病发病的独立影响因素。
Objective To investigate the distribution of erythrocyte distribution width (RDW) in peripheral blood of patients with coronary heart disease (CHD) and to explore its clinical value. Methods A total of 227 patients with CHD as coronary heart disease and 198 healthy subjects as healthy controls were enrolled in this study. The peripheral blood RDW level was determined by blood analysis system. The levels of C-reactive protein (CRP), interleukin-2 (IL-2) ), Interleukin-6 (IL-6) and tumor necrosis factor (TNF), to discuss their relevance. Results The distributions of RDW3 and RDW4 in CHD group were more than those in healthy control group (P <0.01). The levels of CRP and TNF in CHD group increased with the increase of quartile of RDW. Spearman correlation analysis showed that RDW and CRP levels were positive (R = 0.171, P = 0.036 <0.05). Smoking, hypertension and RDW were the independent influencing factors of coronary heart disease (P <0.05). Conclusion The level of RDW is correlated with coronary heart disease and may be used as an independent factor in the pathogenesis of coronary heart disease.