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维生素 A 对人和其它动物的表皮有一种保护作用。Robert 等人已证明给鼠服用前列腺素有预防胃溃疡的可能性,这是一种叫做“胃细胞保护”的不同于抑制胃酸分泌的方法。业已证明,维生素 A 和其它类胡萝卜素对鼠用96%乙醇和0.6M/L 盐酸胃内给药而产生的急性胃粘膜损伤也有这种保护作用。维生素 A 并不抑制鼠的胃酸分泌。本文报道了维生素 A 对60名慢性胃溃疡病人的胃细胞保护作用的对照试验结果,作者把病人分为三组:A 组口服使胃痛减轻的必需剂量的抗酸药碳酸氢钠,碳酸钙和三硅酸镁;B 组口服抗酸药(同 A 组)并加3×50.000单位的维生素 A;C 组治疗方法同 B 组,并每天加服3×4mg 的赛庚啶(cyproheptadine)。治疗持续4周,其间有4名病人因家庭原因退出试验,治疗开始和结束时作内窥镜检查,用测面积法测量溃疡大小。卞益民
Vitamin A has a protective effect on the epidermis of humans and other animals. Robert et al. Have shown that the administration of prostaglandins to mice has the potential to prevent gastric ulcers, a process that is different from the inhibition of gastric acid secretion called “gastric cell protection.” It has also been shown that vitamin A and other carotenoids also have this protective effect on acute gastric mucosal injury in mice administered with 96% ethanol and 0.6 M / L hydrochloric acid intragastrically. Vitamin A does not inhibit gastric acid secretion in rats. This paper reports the results of a controlled trial of vitamin A on gastric cell protection in 60 patients with chronic gastric ulcer. The authors divided the patients into three groups: Group A, the oral antacid sodium bicarbonate, calcium carbonate and Group A was treated with oral antacid (group A) with 3 × 50.000 units of vitamin A; group C was treated with group B and 3 × 4 mg of cyproheptadine daily. The treatment lasted for 4 weeks, during which 4 patients withdrew from the test due to family reasons, endoscopy was performed at the beginning and end of the treatment, and the ulcer size was measured by the area measurement method. Bian Yimin