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目的：以“证治药动学”假说为理论指导，探索中医“证”对药代动力学的影响。方法：１１２只ＳＤ大鼠随机分为两组：Ι为对照组，Ⅱ为脾虚组。用猪油灌胃法制备大鼠脾虚模型，测给药后不同时间点血中磺胺嘧啶浓度和给药后１小时磺胺嘧啶的肝脑分布。结果：脾虚组在各时间点的血药浓度及给药后１ｈ的肝脑分布与正常组无显著差异。结论：动物“证”模型与临床“证”具有较大差异，探索“证”对药代动力学影响宜选临床患者。
OBJECTIVE: To use the hypothesis of “Syndrome Pharmacokinetics” as a theoretical guide to explore the influence of Chinese medicine syndrome on pharmacokinetics. METHODS: One hundred and twelve SD rats were randomly divided into two groups: Ι was the control group and II was the spleen deficiency group. A rat model of spleen deficiency was prepared by intragastric administration of lard to measure the concentration of sulfadiazine in blood at different time points after administration and the liver and brain distribution of sulfadiazine at 1 hour after administration. Results: There was no significant difference between the plasma concentration of the spleen deficiency group and the distribution of liver and brain at 1 h after administration in the spleen deficiency group compared with the normal group. Conclusion: There is a big difference between the animal “certificate” model and the clinical “certificate”. To explore the effect of “certificate” on the pharmacokinetics, clinical patients should be selected.