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已知血中高密度脂蛋白(HDL)降低增加冠心病的发病率,19-去甲睾酮衍生的孕激素可降低HDL水平,因此寻找对HDL无影响的其他孕激素避孕药有很大的意义,本研究采用一种新的孕激素ST-1435(16-亚甲-17α-乙酰氧基-19-去甲-4-孕炔-3、20-二酮),此种孕激素有高的避孕效果而无雄激素活性,由于其在胃肠道内很快代谢且难于吸收,故口服基本无效,而胃肠道外给药有高的活性。ST-1435置于外径为2.4mm、长为7.5mm或
It is known that lowering of blood high density lipoprotein (HDL) increases the incidence of coronary heart disease. 19-nortestosterone-derived progestin can reduce the level of HDL. Therefore, it is of great significance to find other progestin contraceptives that have no effect on HDL, In this study, a new progestin ST-1435 (16-methylene-17α-acetoxy-19-nor-4-pregnane-3,20-dione) The effect of androgen-free activity, due to its rapid metabolism in the gastrointestinal tract and difficult to absorb, so orally basically ineffective, while parenteral administration with high activity. ST-1435 placed in an outer diameter of 2.4mm, length of 7.5mm or