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目的:验证参芪扶正注射液的临床疗效。方法:随机分为3组比较疗效。化疗加参芪组(治疗组,化疗加静脉滴注参芪扶正注射液)62例,化疗对照组(化疗组,单用化疗)37例,单纯参芪组(参芪组,单用参芪扶正注射液)21例。观察疗效,并观察自然杀伤(NK)细胞、巨噬细胞及T细胞亚群等治疗前后变化。结果:治疗组对胃癌癌灶的缓解率为161%,稳定率为871%,化疗组为135%和649%,组间比较稳定以上率有显著性差异。对气虚证及生存质量的改善疗效也很明显,治疗组分别为758%和435%,参芪组是619%和571%,化疗组为351%和297%。对骨髓造血功能也有较好的维护作用,治疗组白细胞治疗后低于4×109/L者占48%,化疗组为216%,组间有显著性差异。同时能提高NK细胞、巨噬细胞、T淋巴细胞亚群的活性。临床用药安全可靠,无明显不良反应,对心、肝、肾等主要脏器无损伤作用。结论:参芪扶正注射液配合化疗对胃癌癌灶有一定的缓解和稳定作用,对气虚患者,临床疗效显著,用药安全可靠。
Objective: To verify the clinical efficacy of Shenqi Fuzheng Injection. Methods: Randomly divided into three groups of comparative efficacy. Chemotherapy plus Shenqi group (treatment group, chemotherapy plus intravenous drip Shenqi Fuzheng injection) in 62 cases, chemotherapy control group (chemotherapy group, chemotherapy alone) in 37 cases, pure Shenqi group (Shenqi group, alone Fuzheng Injection (21 cases). The curative effect was observed, and the changes before and after treatment such as natural killer (NK) cells, macrophages, and T cell subsets were observed. Results: The remission rate in the treatment group was 16.1%, the stable rate was 87.1%, and the chemotherapy group was 13.5% and 64.9%. There was a significant difference between the two groups. The efficacy of qi deficiency and quality of life was also significantly improved. The treatment group was 75.8% and 43.5%, respectively, the Shenshen group was 61.9% and 57.1%, and the chemotherapy group was 35.1% and 29. 7%. Hematopoietic function of the bone marrow also has a good maintenance effect, the treatment group after leukocyte treatment was less than 4 × 109/L, accounting for 4.8%, chemotherapy group was 21.6%, there was a significant difference between the groups. At the same time can increase the activity of NK cells, macrophages, T lymphocyte subsets. The clinical medication is safe and reliable, with no obvious adverse reactions and no damage to the main organs such as heart, liver and kidney. Conclusion: Shenqi Fuzheng Injection combined with chemotherapy has a certain remission and stabilization effect on gastric cancer, and it has significant clinical effect on qi deficiency patients. It is safe and reliable.