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目的:评价盐酸戊乙奎醚对离体大鼠子宫收缩的影响。方法:采用乙酰胆碱(Ach)致大鼠离体子宫痉挛模型,测量给予盐酸戊乙奎醚后大鼠离体子宫条痉挛收缩的最大张力,用经典的Schild方法计算受试药的pA2值。实验同时使用非选择性胆碱受体阻滞剂阿托品和选择性M2受体阻滞剂加那胺(gallam ine)作阳性对照药。结果:盐酸戊乙奎醚的pA2值显著大于硫酸阿托品pA2值[(12.19±1.10)vs(9.36±2.30),P<0.05],与加那胺的pA2值接近(12.49±2.20)。盐酸戊乙奎醚对离体大鼠子宫抗Ach痉挛的松弛作用强度明显大于硫酸阿托品。结论:盐酸戊乙奎醚能有效地缓解离体大鼠子宫的痉挛状态。
Objective: To evaluate the effect of penehyclidine hydrochloride on uterine contraction in isolated rat. Methods: The model of isolated rat uterine spasm induced by acetylcholine (Ach) was used to measure the maximal tension of isolated rat uterine spasm contraction after penehyclidine hydrochloride was administered. The pA2 value of the tested drug was calculated by classical Schild method. The experiment used both the non-selective cholinergic receptor blocker atropine and the selective M2 receptor blocker gallam ine as a positive control. Results: The pA2 value of penehyclidine hydrochloride was significantly higher than that of atropine sulfate [(12.19 ± 1.10) vs (9.36 ± 2.30), P <0.05], and pA2 value with guanamine was (12.49 ± 2.20). Penehyclidine hydrochloride on isolated rat uterine anti-Ach spasm relaxation strength was significantly greater than atropine sulfate. Conclusion: Penehyclidine hydrochloride can effectively relieve the spasticity of isolated rat uterus.