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目的:确定小儿蛛网膜下腔麻醉罗哌卡因(批号:8070031FP齐鲁制药)的半数有效安全剂量,剂量按脊柱长度(即第1颈椎至骶裂孔的距离)计算。方法:50例,ASA级,5岁以上小儿,下肢及下腹部手术时,L3～4间隙行蛛网膜下腔穿刺,第1例0.13mg/cm,应用序贯法确定下一例小儿的药物剂量,相邻剂量的差值为0.01mg/cm。注药15min后,以手测麻醉平面在L1至T4视为安全有效。结果:所有小儿均顺利完成手术,无排除病例。结论:小儿蛛网膜下腔麻醉时罗哌卡因的ED50有效剂量为0.135mg/cm,95%的可信区间为0.12～0.15mg/cm。
Objective: To determine the effective dose of half the effective dose of ropivacaine (Lot: 8070031FP Qilu Pharmaceutical) in children with subarachnoid anesthesia. The dose was calculated according to the length of the spine (that is, the distance from the first cervical vertebra to the sacral fissure). Methods: 50 cases, ASA grade, over 5 years of age pediatric, lower extremity and lower abdomen surgery, L3 ~ 4 space subarachnoid puncture, the first case of 0.13mg / cm, sequential method to determine the next case of pediatric drug dose , The difference between the adjacent dose of 0.01mg / cm. 15min after injection, to test the anesthesia plane in L1 to T4 as safe and effective. Results: All children successfully completed the operation without exception. CONCLUSIONS: The ED50 effective dose of ropivacaine for pediatric subarachnoid anesthesia is 0.135 mg / cm and the 95% confidence interval is 0.12 to 0.15 mg / cm.