为研究ＩｇＡ肾病时肾小管上皮细胞的病变，用右旋糖酐诱发小鼠ＩｇＡ肾病。结果为：ＩｇＡ肾病的主要超微病变为肾小球系膜细胞轻度增生，系膜基质及血管球基膜内有电子致密物沉积。同时，肾小管上皮细胞内线粒体肿大、嵴减少、断裂或消失，内质网扩张，髓样小体增多。以上结果表明：ＩｇＡ肾病时，病变波及肾小管上皮细胞 To study the renal tubular epithelial cells during IgA nephropathy, dextran induced mouse IgA nephropathy. The result was that the major superficial lesion of IgA nephropathy was mild glomerular mesangial cell hyperplasia with deposition of electron-dense material in the mesangial matrix and the vascular balloon basement membrane. At the same time, tubular epithelial cells within the mitochondria, crest reduction, rupture or disappearance, endoplasmic reticulum dilated, myeloid bodies increased. The above results show that: IgA nephropathy, lesions affecting renal tubular epithelial cells