论文部分内容阅读
目的:探讨使用芬太尼透皮贴剂治疗老年肺癌患者中重度癌痛的有效性及安全性。方法:38例伴有中重度疼痛的晚期老年肺癌患者,给予芬太尼贴剂,初始剂量为25μg.h-1。观察治疗前后疼痛强度、生活质量评分和药物不良反应。结果:总有效率92.1%,其中完全缓解10例(26.3%),部分缓解25例(65.8%),轻度缓解2例(7.9%)。不良反应有恶心、便秘、头昏和呕吐等。没有发生严重肝肾功能损害及呼吸抑制。所有患者的生活质量均明显提高。结论:芬太尼贴剂能有效缓解老年肺癌患者中重度癌痛,不良反应轻,使用安全方便,并能改善患者的生活质量,可作为老年患者中重度癌痛治疗的首选。
Objective: To investigate the efficacy and safety of using fentanyl transdermal patch in the treatment of severe cancer pain in elderly patients with lung cancer. Methods: Thirty-eight patients with advanced lung cancer who had moderate-severe pain were given fentanyl patch at an initial dose of 25 μg.h-1. The pain intensity, quality of life score and adverse drug reactions were observed before and after treatment. Results: The total effective rate was 92.1%, of which 10 (26.3%) were completely relieved, 25 (65.8%) partially relieved and 2 (7.9%) slightly relieved. Adverse reactions are nausea, constipation, dizziness and vomiting. No serious liver and kidney dysfunction and respiratory depression. All patients had significantly improved quality of life. Conclusion: The fentanyl patch can effectively alleviate the severe cancer pain in elderly patients with lung cancer, light adverse reactions, safe and convenient to use, and can improve the quality of life of patients, can be used as the first choice for the treatment of moderate and severe cancer in elderly patients.