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目的研究2型糖尿病患者自身血尿酸水平以及糖尿病周围神经病变的相关性。方法选取2014年1月—2016年8月许昌市中心医院收治的86例2型糖尿病患者,按照并发症差异分为A组(43例)与B组(43例),A组患者是单纯2型糖尿病,B组患者伴随糖尿病周围神经病变,对比两组各项临床特征以及相关指标。结果 A组病程、甘油三酯、总胆固醇、超敏C反应蛋白、血尿酸水平及神经缺陷评分明显低于B组(P<0.05);Logistic回归分析显示,血尿酸水平、病程以及总胆固醇进入回归方程(P<0.05)。结论 2型糖尿病患者自身血尿酸水平以及糖尿病周围神经病变存在紧密联系,糖尿病周围神经病主要独立危险因素之一是血尿酸,其检测可为综合治疗提供参考。
Objective To study the correlation between serum uric acid level and diabetic peripheral neuropathy in type 2 diabetic patients. Methods 86 patients with type 2 diabetes treated in Xuchang Central Hospital from January 2014 to August 2016 were divided into group A (43 cases) and group B (43 cases) according to the difference of complications. Group A patients were simple 2 Type 2 diabetes mellitus, group B patients with diabetic peripheral neuropathy, comparing the two groups of clinical features and related indicators. Results The course of disease, triglyceride, total cholesterol, high-sensitivity C-reactive protein, serum uric acid and neurological deficit scores in group A were significantly lower than those in group B (P <0.05). Logistic regression analysis showed that serum uric acid level, duration of disease and total cholesterol Regression equation (P <0.05). Conclusions There is a close relationship between serum uric acid level and diabetic peripheral neuropathy in patients with type 2 diabetes mellitus. One of the main independent risk factors of diabetic peripheral neuropathy is blood uric acid. The detection of this disease may provide a reference for comprehensive treatment.