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目的:探讨血浆去甲肾上腺素(NE)、肾上腺素(E)、5-羟色胺(5-HT)浓度与A型行为冠心病心律失常的关系。方法:对60例确诊为冠心病的患者进行A型行为问卷测试,分为A型组32例,B型组28例。用酶联免疫吸附法(ELISA)测定血浆中NE、E、5-HT浓度。结果:A型组NE、E、5-HT浓度分别为(4.32±1.27)ng/ml,(0.79±0.46)ng/ml,(13.20±11.18)ng/ml;B型组分别为(2.27±0.84)ng/ml,(0.34±0.23)ng/ml,(6.16±5.74)ng/ml,两组有显著性差异(P<0.001)。A型组出现室性心率失常12例,占37.5%;B型组出现室性心率失常3例,占10.6%,两组有明显差异(P<0.05)。结论:A型行为的人易紧张,交感神经兴奋,NE、E、5-HT分泌增加,冠脉病变严重,易出现恶性心律失常。
Objective: To investigate the relationship between plasma norepinephrine (NE), epinephrine (E), 5-hydroxytryptamine (5-HT) and type A arrhythmia. Methods: A type A behavioral questionnaire was tested in 60 patients diagnosed as coronary heart disease, divided into type A group of 32 cases and type B group of 28 cases. Plasma concentrations of NE, E, 5-HT were measured by enzyme-linked immunosorbent assay (ELISA). Results: The concentrations of NE, E and 5-HT in type A group were (4.32 ± 1.27) ng / ml and (0.79 ± 0.46) ng / ml and (13.20 ± 11.18) ng / 0.84 ng / ml, 0.34 ± 0.23 ng / ml and 6.16 ± 5.74 ng / ml, respectively. There was significant difference between the two groups (P <0.001). There were 12 cases of ventricular arrhythmia in type A group (37.5%). There were 3 cases of ventricular arrhythmia in type B group (10.6%). There was significant difference between the two groups (P <0.05). Conclusion: A type of behavior is easy to nervous people, sympathetic excitement, increased NE, E, 5-HT secretion, severe coronary lesions, prone to malignant arrhythmia.