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钙拮抗剂通过细胞膜通道流入细胞内,可有两种作用:改变心律或扩张血管。异博停、心痛定、心可定、心舒宁的作用主要是这种方式(心舒宁有另外的作用方式,其包括奎尼丁样作用和轻微的利尿作用)。β—阻滞剂和局部麻醉剂也拮抗钙的流输,但这不是它们的主要作用。在理论上任何钙拮抗剂可以是有效的抗心律失常剂、抗绞痛剂、抗高血压剂和抗心衰剂;但临床经验上它们的这些作用是受限制的,对这些疾病在治疗上的地位尚须进一步确立。
Calcium antagonists flow through the cell membrane channels into the cell, can have two roles: to change the heart rate or dilate blood vessels. Different Bo stop, heartache given, the heart can be fixed, the role of heart Shu Ning mainly in this way (Xingsuning has another mode of action, which includes quinidine-like effect and mild diuretic effect). Beta-blockers and local anesthetics also antagonize calcium transport, but this is not their primary effect. In theory, any calcium antagonist can be a potent anti-arrhythmic agent, an anti-anginal agent, an antihypertensive, and an anti-heart failure agent; however, their clinical utility is limited in their treatment of these diseases The status still needs to be further established.