【摘 要】
：
In order to identify the potential nephrotoxic compounds in traditional Chinese medicine Lithospermum erythrorhizon,it was separated into serial fractions accor
【机 构】
：
Tianjin State Key Laboratory of Modern Chinese Medicine,College of Preclinical Medicine,College of P
论文部分内容阅读
In order to identify the potential nephrotoxic compounds in traditional Chinese medicine Lithospermum erythrorhizon,it was separated into serial fractions according to their polarities.An in vitro method was utilized to determine the nephrotoxicity of these fractions with the help of fluorescence image analysis.As a result,the primary fraction A05 and its secondary fractions C06—C09 and C12—C14 were found to have significant toxicity to LLCPK1 cell line,as determined by the survive rate less than 20％ after they were treated with these fractions.These potential nephrotoxic fractions were further analyzed by multistage and high resolution mass spectrometry.The main compounds in these fractions were tentatively identified to be acetylshikonin,isobutyrylshikonin,β,β′-dimethylacryloylshikonin,and isovalerylshikonin,which may bring nephrotoxicity.
其他文献
We present an XMM-Newton observation of the eclipsing binary Algol which contains an X-ray dark B8V primary and an X-ray bright K2Ⅳ secondary. The observation
We have reported that phenyliodonium diacetate[PhI(OAc)2]can serve as an eco-friendly mild oxidant for the epoxidation of alkenes in the presence of Mn(Ⅲ) comp
A novel preparation of aluminum diethylphosphinate (AlPi) was carried out with free-radical addition reaction by means of UV-irradiation under atmospheric press
Let T be a Wakamatsu tilting module. A module M is called (n, T)-copure injective (resp. (n, T)-copure flat) if ε1T(N, M) = 0 (resp. ΓT1(N, M) = 0) for any mo
In order to encapsulate and controlled-release bioactive proteins,three fibrous membranes,i.e.,poly(L-lactide-co-glycolide)(PLGA),hybrid PLGA and chitosan(H-PLG
Let π be an irreducible unitary cuspidal representation of GLm(AQ), m ≥ 2. Assume that π is self-contragredient. The author gets upper and lower bounds of th
A novel, simple, rapid, efficient and environment-friendly method for the determination of trace copper in cereal samples was developed by using dispersive liqu
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7
With some popular tracking methods for free surface,simulations of several typical examples are carried out under various flow field conditions.The results show
The authors study the existence of nontrivial solutions to p-Laplacian variational inclusion systems｛-△pu + ｜u｜p-2 u ∈ (a)1F(u, v), in RN, -△pv + ｜v｜P-2v ∈ (a