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目的探讨布拉氏酵母菌对早产儿胃肠道功能的影响。方法选择2010年1～12月在我院住院、胎龄28～32周的病情稳定、无消化道疾病的早产儿,随机分为观察组和对照组。观察组予以早产儿配方奶加布拉氏酵母菌100mg/(kg·d)口服,对照组予以单纯早产儿配方奶喂养,连续治疗2～4周至校正胎龄34周。观察并比较两组早产儿体重变化、肠道喂养、黄疸、医院内感染、坏死性小肠结肠炎(NEC)及住院时间等情况。结果观察组入选47例早产儿,对布拉氏酵母菌耐受性良好,均未发生真菌血症。与对照组(43例)比较,观察组生理性体重下降至最低值的日龄小[(4.9±1.7)天比(5.7±1.4)天],恢复出生体重快[(11.6±3.8)天比(13.3±3.9)天],接受光疗时间短[(6.1±1.9)天比(7.2±2.9)天],较早达全胃肠道喂养[(18.3±9.2)天比(23.0±12.4)天],住院时间短[(34.2±16.7)天比(42.2±18.8)天],差异均有统计学意义(P<0.05)。两组生理性体重下降比率、黄疸高峰时间和黄疸最高值、开奶时间以及NEC和败血症发生率差异无统计学意义(P>0.05)。结论早产儿对布拉氏酵母菌耐受性好,布拉氏酵母菌能缩短早产儿达全量胃肠道喂养时间、住院天数和黄疸光疗时间。
Objective To investigate the effect of Saccharomyces boulardii on gastrointestinal function in premature infants. Methods Preterm infants admitted to our hospital from January to December 2010 with stable gestational age of 28 to 32 weeks and without gastrointestinal diseases were randomly divided into observation group and control group. The observation group was given oral administration of 100 mg / (kg · d) of the formula milk of premature infant, and the control group was fed with pure preterm infant formula. The treatment was continued for 2 to 4 weeks to the corrected gestational age of 34 weeks. The changes of body weight, intestinal feeding, jaundice, nosocomial infection, necrotizing enterocolitis (NEC) and length of hospital stay in the two groups were observed and compared. Results The observation group was enrolled in 47 cases of premature children, good resistance to B. brasiliensis, no fungal episodes. Compared with the control group (43 cases), the days of age at which the physiological body weight of the observation group decreased to the lowest value [(4.9 ± 1.7) days vs (5.7 ± 1.4 days)], and the birth weight fast [(11.6 ± 3.8) (13.3 ± 3.9) days], shorter phototherapy (6.1 ± 1.9) days compared with (7.2 ± 2.9) days), and earlier total gastrointestinal feeding (18.3 ± 9.2 days vs 23.0 ± 12.4 days ], And shorter hospital stay [(34.2 ± 16.7) days compared with (42.2 ± 18.8) days], the differences were statistically significant (P <0.05). There was no significant difference in physiological weight loss rate, jaundice peak time, jaundice peak value, opening time and the incidence of NEC and septicemia between the two groups (P> 0.05). Conclusions Premature babies are well tolerated with B. pastoris, while B. burgdorferi can shorten the total amount of gastrointestinal feeding, length of hospital stay and jaundice phototherapy time in preterm infants.