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目的研究益智五海胶囊改善血管性痴呆(VD)智力的作用机理。方法采用缺血再灌注法制作VD大鼠模型,检测益智五海胶囊对VD大鼠模型中ET、TXB2、CGRP、6-Keto-PGF1α的影响。结果益智五海胶囊对VD大鼠模型CGRP、6-Keto-PGF1α具有不同的升高作用,ET、TXB2具有不同程度的降低作用。结论益智五海胶囊可改善智能,多途径调节CGRP、6-Keto-PGF1α和ET、TXB2的含量,改善VD的智力障碍。
Objective To study the mechanism of improving the intelligence of vascular dementia (VD) by Zhiwu Capsule. Methods VD rat model was established by ischemic reperfusion and the effects of Yiwu Wuhai Capsule on ET, TXB2, CGRP and 6-Keto-PGF1α in VD rat model were detected. RESULTS: Yiwu Wuhai Capsule had different elevation effect on CGRP and 6-Keto-PGF1α in VD rat model, and ET and TXB2 had different degrees of decreasing effect. Conclusion Zhiwu Wuhai Capsule can improve intelligence, and regulate the content of CGRP, 6-Keto-PGF1α and ET, TXB2 in many ways, and improve the mental retardation of VD.