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目的探讨小窝蛋白1(Caveolin-1)在正常结直肠粘膜、结直肠癌组织中的表达及意义。方法采用免疫组化S-P法,检测82例结直肠癌组织、40例正常结直肠粘膜组织中Caveolin-1的表达水平。结果在结直肠正常粘膜和癌组织中Caveolin-1的表达存在显著差异(P=0.001),癌组织中Caveolin-1表达阳性率(42.68%)明显低于正常粘膜组织(75.00%)。在结直肠癌组织中,Caveolin-1蛋白表达阳性率与结直肠癌的浸润深度呈负相关(P=0.028),且伴发淋巴结转移的结直肠癌组织比未发生转移的结直肠癌组织Caveolin-1表达阳性率明显减弱(31.11%vs.56.76%),差异有统计学意义(P=0.019)。结论Caveolin-1的低表达与结直肠癌的发生、浸润和转移密切相关。
Objective To investigate the expression and significance of Caveolin-1 in normal colorectal mucosa and colorectal cancer. Methods The expression of Caveolin-1 in 82 colorectal cancer tissues and 40 normal colorectal mucosa tissues was detected by immunohistochemical S-P method. Results The expression of Caveolin-1 in normal colorectal mucosa and cancer tissue was significantly different (P = 0.001). The positive rate of Caveolin-1 in cancer tissue was significantly lower than that in normal mucosa (75.00%) (42.68%). In colorectal cancer tissues, the positive rate of Caveolin-1 protein was negatively correlated with the depth of invasion of colorectal cancer (P = 0.028), and the colorectal cancer with lymph node metastasis was significantly lower than those without colorectal cancer -1 expression was significantly decreased (31.11% vs.56.76%), the difference was statistically significant (P = 0.019). Conclusion The low expression of Caveolin-1 is closely related to the occurrence, invasion and metastasis of colorectal cancer.