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目的研究维吾尔族食管鳞癌组织中血管内皮细胞生长因子受体-2(VEGFR-2)表达与食管鳞癌临床病理参数及预后的关系。方法采用免疫组织化学染色SP法,检测2007年1月至2009年9月我院72例食管鳞癌组织[其中男56例、女16例,年龄57(43~79)岁]、28例对应癌旁正常组织中VEGFR-2的表达。随访收集患者5年生存信息,用Kaplan-Meier生存分析法及Cox风险比例模型进行食管鳞癌生存分析。结果食管鳞癌组织中VEGFR-2阳性表达率为80.56%(58/72),而28例癌旁组织中的VEGFR-2均未见阳性表达(0/28),两者差异有统计学意义(P<0.05)。术后随访显示,食管鳞癌组织中VEGFR-2阴性表达组5年总生存率明显高于VEGFR-2阳性表达组(P<0.05),差异有统计学意义。食管鳞癌组织中VEGFR-2的表达与肿瘤的浸润深度、淋巴结转移、远处转移及临床分期密切相关(P<0.05),与肿瘤大小无相关性(P>0.05)。生存分析提示VEGFR-2阳性表达、淋巴结转移、肿瘤分期增加食管鳞癌患者的死亡风险。结论 VEGFR-2可能成为维吾尔族食管鳞癌发生侵袭转移和判断预后的重要指标。
Objective To investigate the relationship between the expression of vascular endothelial growth factor receptor-2 (VEGFR-2) and clinicopathological parameters and prognosis of esophageal squamous cell carcinoma in Uygur esophageal squamous cell carcinoma. Methods 72 cases of esophageal squamous cell carcinoma [male 56 cases, female 16 cases, age 57 (43-79) years old] in our hospital from January 2007 to September 2009 were detected by immunohistochemical SP method. The expression of VEGFR-2 in adjacent normal tissues. Five-year survival information was collected at follow-up. Kaplan-Meier survival analysis and Cox proportional hazard model were used to analyze the survival of esophageal squamous cell carcinoma. Results The positive rate of VEGFR-2 expression in esophageal squamous cell carcinoma was 80.56% (58/72), while the expression of VEGFR-2 was not found in 28 cases of paracancerous tissues (0/28), the difference was statistically significant (P <0.05). Postoperative follow-up showed that the 5-year overall survival rate of VEGFR-2 negative group was significantly higher than that of VEGFR-2 positive group (P <0.05), and the difference was statistically significant. The expression of VEGFR-2 in esophageal squamous cell carcinoma was closely related to the depth of invasion, lymph node metastasis, distant metastasis and clinical stage (P <0.05), but not to the tumor size (P> 0.05). Survival analysis suggests that VEGFR-2 positive expression, lymph node metastasis and tumor staging may increase the risk of death in patients with esophageal squamous cell carcinoma. Conclusion VEGFR-2 may be an important indicator of invasion and metastasis and prognosis of esophageal squamous cell carcinoma in Uighur.