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目的研究降钙素原(PCT)在慢性阻塞性肺疾病(COPD)急性加重期(AE)治疗中的指导意义。方法 98例AECOPD患者,随机分成观察组和对照组,各49例。对照组由医生根据其临床症状判定是否应用抗生素治疗。观察组根据病患血清PCT水平判定是否应用抗生素治疗。对比两组病患临床治疗及预后情况。结果观察组抗生素使用及二度感染所占比例,住院及抗生素使用时间、费用均显著少于对照组,差异均有统计学意义(P<0.05);治疗后两组白细胞计数及C反应蛋白(CRP)水平,差异无统计学意义(P>0.05)。结论 PCT在AECOPD治疗中具有十分重要指导意义,可减少抗生素过度使用及二度感染发生率,进而降低治疗费用。
Objective To study the guiding significance of procalcitonin (PCT) in the treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods AECOPD 98 cases were randomly divided into observation group and control group, 49 cases each. Control group by the doctor according to their clinical symptoms to determine whether the application of antibiotics. The observation group according to the level of serum PCT to determine whether the application of antibiotics. Comparison of two groups of patients with clinical treatment and prognosis. Results The proportion of antibiotic use and secondary infection in observation group was significantly lower than that in control group (P <0.05). The time of hospitalization and antibiotic use and cost were significantly lower than those in control group (P <0.05). After treatment, the white blood cell count and C-reactive protein CRP) levels, the difference was not statistically significant (P> 0.05). Conclusion PCT is of great guiding significance in the treatment of AECOPD, which can reduce the incidence of overuse of antibiotics and secondary infection, thus reducing the cost of treatment.