随着经济的快速发展,心脏疾病的发病率也在快速增长,是引起死亡的主要原因之一。虽然目前已经确定心肌损伤的原因有很多,但对其发病机制的关键分子机制尚未明了。在心肌细胞内的分子过程的调控过程中,转录因子如核因子-κB(NF-κB)在其中发挥重要作用。尤其是NF-κB激活与充血性心力衰竭、心肌肥厚、糖尿病性心肌 With the rapid economic development, the incidence of heart disease is also rapidly increasing, which is one of the major causes of death. Although myocardial damage has been identified for a variety of reasons, the key molecular mechanisms underlying its pathogenesis are unclear. In the regulation of molecular processes in cardiomyocytes, transcription factors such as nuclear factor-κB (NF-κB) play an important role. Especially NF-κB activation and congestive heart failure, cardiac hypertrophy, diabetic myocardium