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小肠切除或空-回肠旁路术后的患者发生钙吸收障碍和骨软化.钙吸收障碍的原因可能包括维生素D缺乏、非可溶性钙盐在肠腔内沉淀、小肠长度减短以及肠粘膜病变等.此类患者常见血浆25-羟基维生素D[25(OH)D]浓度低下,表明维生素D缺乏;有报导1,25-二羟基维生素D[1,25(OH)_2D_3]的血浆浓度降低,如用维生素D治疗,可能改善肠钙吸收障碍.
Calcium absorption disorders and osteomalacia occur in patients who have undergone small-bowel resection or empty-ileal bypass surgery. Causes of calcium imbalance may include vitamin D deficiency, deposition of insoluble calcium salts in the intestine, reduction in the length of the small intestine, and intestinal mucosal lesions (25 (OH) D)], a common plasma 25-hydroxyvitamin D [25 (OH) D] concentration in these patients, indicating a lack of vitamin D. Plasma concentrations of 1,25-dihydroxyvitamin D [1,25 (OH) If treated with vitamin D, may improve intestinal calcium absorption disorders.